Self-Injection Made Easy

3mL cartridges are proven containers to deliver your larger-volume biologics injections. Pii’s 3mL cartridge kit improves patient compliance by supporting a range of therapies that require frequent injections and variable dosing.

Ready-to-Use 3mL Cartridge-Based Is Ideal for High Volume, High Viscosity, Complex Injectables

3mL cartridge pen

The combination of an aging population and more people suffering from chronic diseases is making it difficult for healthcare professionals to effectively treat patients over the long-term, subsequently impacting patient compliance. This has led to increased demand for patient-friendly administration systems, such as single-and dual-chamber cartridges. In fact, industry gurus estimate the global autoinjectors market, which includes cartridge-based systems, to be valued at more than $6.2 billion by 2027.1

3mL machine

Surpasses Injection Volume Limitations

The ready-to-use (RTU) 3mL cartridge-based, single-use is specifically designed to ensure consistency of delivery for high-volume, high-viscosity injectable drug delivery systems.

According to the National Center for Biotechnology Information, subcutaneous (SC) delivery of biologics has traditionally been limited to fluid volumes of 1–2 mL, with recent increases to volumes of about 3mL. This injection volume limitation poses challenges for high-dose biologics, as these formulations may also require increased solution concentration in many cases, resulting in high viscosities which can affect the stability, manufacturability, and delivery/administration of therapeutic drugs.

Currently, there are technologies that can help to overcome these challenges and facilitate the delivery of larger amounts of drug through the SC route. This can be achieved either by enabling biologic molecules to be formulated or delivered as high-concentration injectables (>100 mg/mL for antibodies) or through facilitating the delivery of larger volumes of fluid (>3 mL).2

Glass Cartridges Protect Your Drug

Higher injection volumes and viscosities present a unique challenge to companies as they assess primary packaging component technologies. Primary packaging is of critical importance in biologics as this is the main point of contact between the drug and the device. Additionally, glass is easy to sterilize with heat and can protect medicines from ultraviolet rays. Finally, glass is easily recycled. These are all reasons why the global glass packaging market could reach $7.5 billion by 2028.3

3mL tray

3mL Cartridge Tub & Nested Carrier

An RTU cartridge-handling system offers tight tolerances, precise dimensions, and premium surface quality. Cartridges are delivered pre-sterilized. This standard tub and nest configuration ensures drug stability and optimal performance with all cartridge-based devices, offers maximum compatibility with filling line, and allows for quick and easy changeover.

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3mL cartridge pen
3mL cartridge with callouts x

3mL Cartridge Kit Assembly

The 3mL Cartridge's ease of use, optimized design, and injection reliability is ideally suited to the shift to self-injection. Designed for use with a range of therapies that require frequent injections and/or variable dosing, the 3mL cartridge accommodates a range of patient profiles for disease management.

The RTU 3mL cartridge kit includes:

  • A 3mL cartridge
  • Easy needle attachment and removal
  • Robust proven design based on patient usability and human factor considerations
  • Variable and multi-dose use, simple dose dialing with audible clicks, and large and clear dose markings
  • Variety of pre-developed button options and therapeutic dose ranges

 

3mL Cartridge Robotic Aseptic Fill-Finish Production

The state-of-the-art Genisys® R supports small batch sizes to aseptically and accurately fill 3mL glass cartridges. The innovative Genisys® R enables Pii to continue delivering sterile clinical and commercial supplies with very aggressive timelines.

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