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Pii Center for Pharmaceutical Technology

Together with the University of Mississippi, Pii has established the Pii Center for Pharmaceutical Technology, a center devoted to research related to pharmaceutical processing technologies.

Pii has made a grant to support the Center’s research and the education of graduate students in the pharmaceutics program at UM.

The Center will collaborate with private industry, government agencies and other universities to conduct research aimed at developing novel, cost-effective, patient-friendly and efficacious formulations for delivering new and existing pharmaceutical products. Through this long-term commitment, we are delighted to know our country’s future pharmaceutical researchers will possess a better understanding of advanced and novel pharmaceutical processing technologies and the important role they play in the development of lifesaving medications.

Below you can access the presentations and publications generated as part of Pii’s financial support for the Center. 

Posters:

Formulation Optimization of Hot Melt Extruded Abuse Deterrent Pellets Utilizing Design of Experiments (DOE), SindhuriMaddineni, Xin Feng, Soumyajit Majumdar, Mohammed Rahman, Zhuoyang John Lian, Divya Tewari, Vivian Bi, Thomas Durig, Michael A. Repka. Presented at the 2012 Annual Meeting of the American Association of Pharmaceutical Scientists in Chicago, IL. October 2012.

Development of a Highly Drug Loaded Coenzyme Q10 – Lipid Matrix for Sustained Delivery Utilizing Hot Melt Extrusion, Sindhuri Maddineni, S.N. Murthy, Soumyajit Majumdar, Michael A. Repka.  Presented at the 2012 Annual Meeting of the American Association of Pharmaceutical Scientists in Chicago, IL. October 2012.

Recrystallization Rate Prediction of Melt Extruded Polymeric Amorphous Solid Dispersions, Sejal Shah, Xin Feng, Michael Repka. Presented at the 2012 Annual Meeting of the American Association of Pharmaceutical Scientists in Chicago, IL. October 2012.

Scale-up of the Melt Extrusion Process from Bench Scale to Pilot Scale Extruder by Equalizing Specific Mechanical Energy Inputs, Sejal Shah, Xin Feng, Jiannan Lu, S Narasimha Murthy, Michael Repka. Presented at the 2012 Annual Meeting of the American Association of Pharmaceutical Scientists in Chicago, IL. October 2012.

Development of Pediatric and Geriatric Taste Masked Formulations by Hot Melt Extrusion Techniques, Manjeet Pimparade, Jiannan Lu, Sejal Shah, Soumyajit Majumdar, Mohammed Rahman, Zhuoyang Lian, Divya Tewari, Vivian Bi, Tom Durig, Michael Repka. Presented at the 2012 Annual Meeting of the American Association of Pharmaceutical Scientists in Chicago, IL. October 2012.

Compatibility and Intermolecular Interactions of Melt Extruded APIs with Polymeric Blends, Manjeet Pimparade, Saad Alshahrani, Bader Alsulays, Sejal Shah, Soumyajit Majumdar, Karl Kolter, Nigel Langley, Michael Repka. Presented at the 2012 Annual Meeting of the American Association of Pharmaceutical Scientists in Chicago, IL. October 2012.

Remodeled Recrystallization Kinetics to Predict the Physical Stability of Polymeric Amorphous Solid Dispersions, Xin Feng, S. Shah, Soumyajit Majumdar, M. Rahman, Zhouyang Lian, Divya Tewari, Vivian Bi, T. Durig, M. Repka. Presented at the 2012 Annual Meeting of the American Association of Pharmaceutical Scientists in Chicago, IL. October 2012.

Improving the Solubility and Physical Stability of Carbamazepine using Hot Melt Extrusion, Saad Alshahrani, Bader Alsulays, Sultan Alshehri, Sejal Shah, Soumyajit Majumdar, Karl Kolter, Nigel Langley, Michael Repka. Presented at the 2012 Annual Meeting of the American Association of Pharmaceutical Scientists in Chicago, IL. October 2012.

Characterization of Polymer-drug Interactions during Melt Extrusion Processes, Saad Alshahrani, Bader Alsulays, Manjeet Pimparade, Sejal Shah, Soumyajit Majumdar, Karl Kolter, Nigel Langley, Michael Repka. Presented at the 2012 Annual Meeting of the American Association of Pharmaceutical Scientists in Chicago, IL. October 2012.

Characterization of molecular interactions of Carbamezepine, Clotrimazole and Fenofibrate with Kollidon® VA 64 using Hot Melt Extrusion, Bader Alsulays, Saad Alshahrani, Manjeet Pimparade, Sejal Shah, Soumyajit Majumdar, Karl Kolter, Nigel Langley, Michael Repka. Presented at the 2012 Annual Meeting of the American Association of Pharmaceutical Scientists in Chicago, IL. October 2012.

Evaluation of the Physico-mechanical Characteristics of Pellets of Different Polymer Prepared by Melt Extrusion/ Face-cut Pelletization, A.S. Alshetaili, E.A. Ashour, B.K. Almutairy, S. Shah, S. Majumdar, M.A. Repka. Presented at the 2012 Annual Meeting of the American Association of Pharmaceutical Scientists in Chicago, IL. October 2012.

Formulation and Evaluation of Taste Masked Ketoprofen Pellets Prepared by Melt Extrusion/ Face-cut Pelletization, A.S. Alshetaili, E.A. Ashour, B.K. Almutairy, S. Shah, S. Majumdar, M.A. Repka. Presented at the 2012 Annual Meeting of the American Association of Pharmaceutical Scientists in Chicago, IL. October 2012.

The Utility of Lutrol®F127 as a Matrix Carrier for Solid Dispersions of Carbamazepine, Jiannan Lu, Sejal Shah, Soumyajit Majumdar, Karl Kolter, Nigel Langley, Michael Repka. Presented at the 2012 Annual Meeting of the American Association of Pharmaceutical Scientists in Chicago, IL. October 2012.

Dissolution Behavior of Soluplus®-felodipine Solid Dispersions, Jiannan Lu, Sejal Shah, Abhilasha Singh, Seongbong Jo, Soumyajit Majumdar, Karl Kolter, Nigel Langley, Michael Repka. Presented at the 2012 Annual Meeting of the American Association of Pharmaceutical Scientists in Chicago, IL. October 2012.

Thermal analysis of the miscibility of Soluplus®-felodipine solid dispersions_2012AAPS_Henry_FINAL, Jiannan Lu, Sejal Shah, Abhilasha Singh, Seongbong Jo, Soumyajit Majumdar, Karl Kolter, Nigel Langley, Michael Repka. Presented at the 2012 Annual Meeting of the American Association of Pharmaceutical Scientists in Chicago, IL. October 2012.

Development and Evaluation of Taste-masked Formulations of Mefenamic Acid using Hot Melt Extrusion Techniques, Sultan Alshehri, Saad Alshahrani, Bjad Almutairy, Sejal Shah, Soumyajit Majumdar, Michael Repka. Presented at the 2012 Annual Meeting of the American Association of Pharmaceutical Scientists in Chicago, IL. October 2012.

Influence of Cooling Temperatures on the Stability of Fenofibrate Solid Dispersions Produced by Melt Extrusion, Eman Ashour, Abdulla Alshetaili, Xin Feng, S. Shah, Michael Repka. Presented at the 2012 Annual Meeting of the American Association of Pharmaceutical Scientists in Chicago, IL. October 2012.

Development and Characterization of Taste Masked Hot Melt Extruded Formulations Containing Sildenafil Citrate, Eman Ashour, S. Shah, Soumyajit Majumdar, Mohammed Rahman, Zhuoyang Lian, Divya Tewari, Vivian Bi, Tom Durig, Michael Repka. Presented at the 2012 Annual Meeting of the American Association of Pharmaceutical Scientists in Chicago, IL. October 2012.

Development and Characterization of Taste Masked Acetaminophen Tablets with Ethyl Cellulose ECN7and Klucel™ Utilizing Hot Melt Extrusion, B. K. Almutairy, A. S. Alshetaili, S. M. Alshehri, S. Shah, S. Majumdar, M. A. Repka. Presented at the 2012 Annual Meeting of the American Association of Pharmaceutical Scientists in Chicago, IL. October 2012.

Development and Characterization of Taste Masked Hot Melt Extruded Formulations Containing Sildenafil Citrate, Joseph Morott, S. Shah, S. Majumdar, Mohammed Rahman, Zhuoyang Lian, Divya Tewari, Vivian Bi, Thomas Durig, M. Repka. Presented at the 2012 Annual Meeting of the American Association of Pharmaceutical Scientists in Chicago, IL. October 2012.

IVIVC of Immediate Release Formulations of a Water Insoluble Drug, Zotepine-Produced by Hot Melt Extrusion, Prashanth Manda, Sindhuri Maddineni, Michael Repka, Satyanarayana Murthy. Presented at the 2012 Annual Meeting of the American Association of Pharmaceutical Scientists in Chicago, IL. October 2012.

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